Cluneal Nerve Entrapment

By Nick Ng
Copy and pasted from: http://www.massagefitnessmag.com/whats-the-news/trapped-cluneal-nerves-may-be-primary-reason-of-certain-low-back-pain

Trapped Cluneal Nerves May Be Primary Reason of Certain Low Back Pain

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Illustration: Gray’s Anatomy
For many years, I used to think low back pain is a muscle or spine problem or pinched nerves in the spine. After having read much of the history of pain science and the research by Dr. Ronald Melzack, Dr. Patrick Wall, and Dr. Joel Katz (gate-control theory, neuromatrix theory, phantom pain), low back pain is much more than just “something is wrong with my tissues.” (1,2,3) Although psychosocial factors can affect pain intensity and the perception of pain in general,(4,5) sometimes low back pain can primarily be caused by biological factors, such as irritated or “entrapped” cluneal nerves.

PictureIllustration: Bethesda Spine Institute

Entrapment of these cutaneous nerves of the buttocks was once described as the tendency for the cluneal nerves to get entrapped where they pass through the fascia near the iliac crest. (6) However, Tubbs et al. stated that such entrapment is uncommon yet possible, and they did not find “no osteofibrous tunnels or obvious compression sites” that could cause these nerves to get “stuck” among 20 cadavers. (7) They suggested that more obvious and common causes of low back pain and leg pain should be ruled out before considering entrapped cluneal nerves be a possibility. “We found no anatomical variation between sex, age or side,” lead author Dr. Shane Tubbs told Massage & Fitness Magazine in an online interview.

However, Aota cited a few studies that yielded some evidence that “suggested entrapment of the penetrating nerves within or under the ligament is a potential cause for [low back pain] and peripartum pelvic pain” because “primary and secondary loops of the posterior sacral nerve plexus passed through or underneath the LPSL. (8,9,10) It appears that this is quite a controversial topic, especially so little is known about cluneal nerves and their role in contributing to pain.

However, in cases where cluneal nerve entrapment is more likely, this condition makes up about 12 percent of reported chronic low back pain and half of this population reported leg pain as well. (11) Most of this entrapment — clunealgia — stem from the superior cluneal nerves (SCN), which pass between the iliac crest and lumbar of gluteal fascia attaching to the crest. Medial cluneal nerves (MCN) are less likely to cause clunealgia because of their shorter length and course through multiple layers of fascia. (7)
Most physicians would diagnose clunealgia by palpation along the iliac crest or long posterior sacroiliac ligament under the patients responds to tenderness or pain relief after a local anesthetic injection. (11)

Dr. Yoichi Aota, who is a physician and researcher at the Yokohama Brain & Spine Center in Yokohama, Japan, cited, “SCN tender point was on the posterior iliac crest approximately 70 mm from the midline and 45 mm from the PSIS. The MCN tender point was on the LPSL within 40 mm caudal to the PSIS.” But these palpation methods are not very reliable. (11)

Dr. Aota told Massage & Fitness Magazine online that very few doctors and surgeons know much about clunealgia or even the anatomy of cluneal nerves when he started to investigate this topic. “I started this study about 12 years ago. At that time, literature in this topic is very limited. No information was available in the text book of orthopaedics and spine surgeries,” Dr. Aota described. “Surgical report was only [reported] by Maigne in France. Although Maigne reported SCN entrapment is a rare cause of low back pain, I found many patients in my clinic [have such pain]. Moreover, half of my patients have not only low back pain but also leg pain.”

“After having experienced SCN surgery, I found many patients have pain at MCN. I think that most of MCN entrapments were treated as sacroiliac joint problem because few doctors know MCN entrapment,” Dr. Aota said.

So he and a team of physicians, surgeons, and researchers at the clinic conducted a pretty large prospective study from 2009 to 2013 that included 834 patients with severe chronic low back pain and/or leg pain. Only 113 of them were diagnosed with SCN pain. When less invasive treatments failed to reduce sufficient pain, surgery was performed on 19 patients to decompress the SCN and remove the SCN block. The surgery had some success. Among 16 patients with leg pain, three had complete pain relief, two had almost complete relief, and three had no improvement. Among the eight remaining patients, they all had some pain relief within the six months of follow-up, and five of them had temporary relapse of pain post-surgery. (13)

While not everyone had sufficient pain relief with surgery, Dr. Aota noted that more than three days of pain relief after blocks had better pain outcomes than those with less than three days of relief.


Dr. Aota isn’t the only one who thinks that this etiology is under-diagnosed. Dr. Tubbs, who is the Chief Scientific Officer of Seattle Science Foundation in Seattle, Washington, told us that the “prevalence of cluneal nerve entrapment is not known but is probably under-diagnosed due to a lack of awareness among medical practitioners.

“It is not known if cluneal nerve entrapment could be asymptomatic but probably not. As with any nerve, they do not like to be irritated and react accordingly,” Dr. Tubbs explained, “because most pain physicians and spine surgeons do not know much about it.”


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M&F: Is cluneal nerve entrapment a cause for back and/or hip pain? Do some people have entrapped cluneal nerves with NO pain? 

Aota: Since the cluneal nerve consists of superior , middle, and inferior cluneal nerves, the superior and middle cluneal nerves (SCNs and MCNs) can be entrapped and cause repetitive friction of the nerves, causing low back pain and leg pain or tingling sensation. And so, cluneal neuralgia can cause mainly low back pain. Leg pain and/or tingling often be associated. Patients with severe pain usually have low back pain radiating leg area and occasionally in the inguinal area.  This may resemble hip pain.

Clinically, repetitive nerve blocks do work well. But when the blocks eliminate pain, pain completely disappear.

Because I have seen only patients with pain, I do not know if some people have entrapped cluneal nerves with NO pain. If people do not have pain even with some degree of entrapment, these situations may be referred to as “entrapment without pain.” Typical patients with mild entrapment have repetitive acute pain occurring several times per year. Pain usually is aggravated by movement. This would disturb exercise, such as playing golf. Some patients with chronic and severe entrapment have very severe  leg pain lasting all day long  radiating to the legs.

Tubbs: Bone grafting from the iliac crest is probably one of the most common reasons to injury these nerves, but other regional surgical procedures could do the same. As the cluneals all have an origin from the spinal nerves or their branches, spine operations could result in their injury.

M&F: What causes cluneal nerves to get “stuck?”

Aota: Superior cluneal nerve passes  between iliac crest and lumbar of gluteal fascia attaching to the crest. Middle cluneal nerve (MCN) passes  through a ligament around sacroiliac joint (long posterior sacroiliac ligament). Because humans are bipedal and keep certain postures, such as flexion, posture increases loads in back and buttock muscles and long posterior sacroiliac ligament, which may make SCNs and MCNs to be at great risk of causing pain by irritating these areas.

Although young patients, like teenagers, sometimes have SCN pain, a majority of SCN and MCN patients are older than 50. That is why I believe that  aging is one of the contributing factors. Spinal instability at thoraco-lumbar junction may initiate cluneal neuralgia because the SCN originates from this area. Spinal kyphosis following osteoporotic vertebral fractures may often aggravate cluneal neuralgia because the nerve is stretched by kyphosis.


M&F: What can physiotherapists and massage therapists do for patients with such pain? And what should they NOT do? 

Aota: Twelve years ago, many of such information was available from massage therapists or acupuncturists. I was interested to find that no doctors know about this clinical entity whereas many massage therapists knows this. Perhaps, this is because these therapists routinely touch patients. However, we (spine surgeons) do not know the tender points and never touch SCN or MCN points in the clinical situation.

During surgeries, I  often observed  adhesion  around the nerves.  I believe that stretch exercise may prevent adhesion.  However, when the pain is severe, exercise may aggravate the pain.

M&F: Why did you choose to do this research? 

Aota: This is GREAT and THE MOST IMPORTANT QUESTION.

I started this study about nine years ago. At that time, literature in this topic is very limited. No information was available in the text book of orthopaedics and spine surgeries.  Surgical report was only by Maigne in France. Although Maigne reported  SCN  entrapment as a rare cause of  low back pain, I found many patients in my clinic to have such pain.  Moreover, half of my patients have not only low back pain but also leg pain.

Tubbs: Pain syndromes are a big problem, especially back pain. Sometimes, other pathologies in the area can result in pain that is referred to the back. One issue is cluneal nerve entrapment, which is scantly mentioned in the medical literature.

M&F: Is surgery the only way to alleviate pain? If so, how successful are surgeries to alleviate pain? Do most patients have no pain after surgery?

Aota: Repetitive nerve blocks work well in the majority of patients. If pain is gone, I encourage patients to do some sports or exercise, such as yoga, to prevent adhesions as I stated above.

IF blocks do not work well, I would select surgical release. As stated in the paper you read, new pain and longer pain relief  after nerve blocks are good candidates.  If pain remains or reappears, I recommend to use radio-frequency treatment (RF) therapy.

M&F: Because of the dearth of literature on the role of cluneal nerve on low back pain, I presume that this isn’t taught much in most manual therapy schools. What do you think would manual therapists (e.g. physical therapists, massage therapists) learn from this? How would this guide their treatment for someone with low back pain after having such surgery?

Tubbs: Most professional anatomy course do not teach about the cluneal nerves. Even many medical curricula leave these out. Therapists (my wife is an occupational therapist) should be at least aware of these nerves as they will undoubtedly have patients with pain in their distribution and will probably be manually stimulating these branches during some of their treatments. This is not clear as the cluneal pain might be interpreted precisely or lumped together as “back pain.”

I’ve taught anatomy to just about every medical and medically related profession over the years and each want to emphasize various things, and this is usually mandated by a lack of time to cover everything.

Massage & Fitness Magazine thanks Dr. Aota and Dr. Tubbs for their time and effort to respond our questions.

References

1. Moayedi M, Davis KD. Theories of pain: from specificity to gate control. J Neurophysiol. 2013 Jan;109(1):5-12. doi: 10.1152/jn.00457.2012. Epub 2012 Oct 3.

2. Melzack R, Katz J. Pain. WIREs Cogn Sci 2013, 4:1–15. doi: 10.1002/wcs.1201.

3. Melzack R, Israel R, Lacroix R, Schultz G. Phantom limbs in people with congenital limb deficiency or amputation in early childhood. Brain. 1997 Sep;120 ( Pt 9):1603-20.

4. Ramond-Roquin A1, Bouton C, Gobin-Tempereau AS, Airagnes G, Richard I, Roquelaure Y, Huez JF. Fam Pract. Interventions focusing on psychosocial risk factors for patients with non-chronic low back pain in primary care–a systematic review. 2014 Aug;31(4):379-88. doi: 10.1093/fampra/cmu008.

5. Synnott A, O’Keeffe M, Bunzli S, Dankaerts W, O’Sullivan P, O’Sullivan K. Physiotherapists may stigmatise or feel unprepared to treat people with low back pain and psychosocial factors that influence recovery: a systematic review. J Physiother. 2015 Apr;61(2):68-76. doi: 10.1016/j.jphys.2015.02.016.

6. Aota Y. Entrapment of middle cluneal nerves as an unknown cause of low back pain. World Journal of Orthopedics. 2016;7(3):167-170. doi:10.5312/wjo.v7.i3.167.

7. Tubbs RS, Levin MR, Loukas M, Potts EA, Cohen-Gadol AA. Anatomy and landmarks for the superior and middle cluneal nerves: application to posterior iliac crest harvest and entrapment syndromes. J Neurosurg Spine. 2010;13:356–359.

8. Maigne JY, Doursounian L: Entrapment neuropathy of the medial superior cluneal nerve. Nineteen cases surgically treated, with a minimum of 2 years’ follow-up. Spine. 1997, 22: 1156-1159. 10.1097/00007632-199705150-00017.

9. Grob KR, Neuhuber WL, Kissling RO. [Innervation of the sacroiliac joint of the human] Z Rheumatol. 1995;54:117–122

10. McGrath MC, Zhang M. Lateral branches of dorsal sacral nerve plexus and the long posterior sacroiliac ligament. Surg Radiol Anat. 2005;27:327–330.

11. Kuniya H, Aota Y, Kawai T, Kaneko K, Konno T, Saito T. Prospective study of superior cluneal nerve disorder as a potential cause of low back pain and leg symptoms. Journal of Orthopaedic Surgery and Research. 2014;9:139. doi:10.1186/s13018-014-0139-7.

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